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KMID : 1134820000290040726
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Journal of the Korean Society of Food Science and Nutrition
2000 Volume.29 No. 4 p.726 ~ p.731
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Inhibitory Effect of Salvia miltiorrhiza Extract on Growth of Some Cancer Cells
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Cheng Guo-Can
Lee Ji-Young
Kim Dong-Chung
Suh Sung-Ock
Hwang Woo-Ik
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Abstract
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This study was performed to evaluate the antitumor activities of water and ethanol (EtOH) extract of Salvia miltiorrhiza in vitro and in vivo. The proliferation of the human hepatoma (HepG2), rectum cancer (HRT-18) and colon cancer (HT-29) cells was inhibited by administration of extracts in a dose- dependent manner. Particularly, EtOH extract inhibited proliferation of the cells more effectively than water extract did. The morphology of cells induced by EtOH extract was characterized by reduction of cell size and deformation. Oral administration of the EtOH extract (3 mg/head) to tumor-bearing mice inhibited the tumor (sarcoma-180) growth by 35% and prolonged their survival rate by 61%. The EtOH extract was shown to be nontoxic at 37.5 mg/head/day on the acute toxicity test. These studies suggest that the EtOH extract of Salvia miltiorrhiza may have antitumor activity in vitro and in vivo.
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KEYWORD
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antitumor activity, Salvia miltiorrhiza, EtOH extract
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